312 Hydroquinone use increases the risk of leukemia and lymphoma in humans

Hydroquinone (HQ) is an effective skin bleaching agent which decreases melanin production by inhibiting tyrosinase. Animal studies have established that HQ may function as a carcinogen directly damaging DNA, and recent study has shown use increases the risk of melanoma nonmelanoma cancers in humans. Daily topical can result accumulation both product its metabolites because dermal absorption more rapid than renal excretion. The present was created to determine whether hydroquinone exposure humans leukemias lymphomas, are been occur with increased frequency patients exposed DNA-damaging agents. TriNetX research platform used for this study. provides access anonymous medical information approximately 99 million 75 large healthcare organizations. Two patient cohorts were created, each having no prior diagnosis leukemia or lymphoma identified International Classification Diseases-10 (ICD-10) codes C81 through C96. One cohort had history (medication code 5509), while other did not. After balancing gender, race, ethnicity, 65,874 arm. then evaluated outcomes (ICD-10 C90 C96) C81-C88). Patients found be 11.4 times likely develop (95% CI (7.0,18.4), P<0.0001) 8.3 (5.7,12.3), P<0.0001). This reveals associated lymphoma. exact mechanisms causing not well defined but due direct damage DNA molecule.